Scripting all the things
For AI in genomics as it currently stands, there's an aspect I haven't seen mentioned that has been on my mind. In short, it's easier to provide more complex, powerful, and complete functionality to users without them being overwhelmed simply because they can use an LLM. And that a way to expose more functionality is to provide a scripting interface to a command-line tool or low-level library. We can drop the docs into a custom GPT or a SKILL.md and the user can use the full power by writing plain-text prompts.
This can, of course, work for command-line tools without a scripting interface. Likewise, claude or codex or pi can help a user to modify low-level code, but if there's already a scripting interface, like there is for vcfanno or slivar, then it's quite powerful and reduces the maintainence burden.